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If you are interested in managing healthy cholesterol levels or healthy blood pressure you should be taking Co-enzyme Q10. Go here to find out why!
Coenzyme Q10 is necessary for supporting energy production, immune function and repair and maintenance of tissues. It also supports healthy cell function. It is a powerful anti-oxidant. It is widely used in Japan for cardiovascular support and is also being used by some heart specialists in the USA. Everyone needs to take CoQ10 for cardiovascular health but especially those on blood pressure reducing drugs and cholesterol reducing drugs(Statins).
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History:
Coenzyme Q10 was first isolated from the mitochondria of beef heart as a yellow substance by Dr. Frederick Crane in 1957 then working at University of Wisconsin, well known for its vitamin researches in the mid 20th century. In 1958, Dr. Folkers and collaborators at Merck synthesized Coenzyme Q10 in the laboratory. By mid 1980, Coenzyme Q10 became widely available as a commercial product and became increasingly popular.
Background:
Coenzyme Q10, or ubiquinone, is a vitamin-like substance which is made by our bodies. It can also be obtained from the diet, being found mainly in oily fish such as salmon, sardines and mackerel as well as organ meats and peanuts. It is essential for the health of all human tissues and organs.
In the body, coenzyme Q10 is found in the mitochondria of cells. The highest proportion of mitochondria are found in organs that do the most work, notably the liver, muscle tissue and the heart. Mitochondria are the intracellular structures that manufacture ATP (Adenosine Triphosphate), the basic energy molecule of cells. Through a series of chemical reactions food is broken down to its component parts and these are combusted with oxygen to make a unit of ATP.
Supplementation of coenzyme Q10 becomes appropriate when its synthesis is impaired through nutritional deficiency, when there is a genetic or acquired defect in synthesis or when there is increased tissue need due to a particular medical condition. These states all interfere with the coenzyme Q10 pathway - a pathway that results in physical energy.
Our ability to absorb or produce coenzyme Q10 deteriorates with age. The decline of coenzyme Q10 levels with time might be linked to the aging mechanism and therefore play a causative role in aging itself.
Benefits
In 1964, Coenzyme Q10 was shown to provide nutrient support for heart health by a Japanese scientist. The success of the use of Coenzyme Q10 was attributed to its energizing effect on heart muscles. The heart has high energy requirements and also high concentrations of coenzyme Q10. Because natural stores drop with age, focus has turned to coenzyme Q10 as a cardiac nutrient. Despite the relatively long history and excellent reputation, many clinicians and health care professionals in the US, let alone the general public, are not well informed about this wonderful nutrition. Lack of interest of large pharmaceutical companies that seek patentable and more profitable drug items as well as lack of interest of many of the health practitioners to read research reports contributed to low popularity. The situation in Europe and Japan is quite different, and Coenzyme Q10 is better known and more popular there.
Coenzyme Q10 acts as an antioxidant which scavenges harmful free radicals, supports the function of vitamin E in the body and also helps recycle vitamin E. The antioxidant function of coenzyme Q10 may enhance its role in supporting cardiovascular health.
Coenzyme Q10 may support exercise tolerance by helping muscle cells use oxygen. It may therefore be of some use to athletes wanting to maximise their performance. Coenzyme Q10 also supports the flow of oxygen within individual cells.
The optimal functioning of the immune system relies on a number of nutrients including Coenzyme Q10. It appears to be non-toxic and well tolerated, even at high doses (100-150mg a day).
Numerous scientific researches and human clinical trials have been performed on Coenzyme Q10, and in the year 1978, a British scientist Dr. Peter Mitchell was awarded Nobel Prize in chemistry for his study in the role of Coenzyme Q10 in cellular energy production mechanism.
Caution:
Should not be taken by pregnant or lactating women, unless under the supervision of a health care professional, due to a lack of studies done on this group of the population in regards to the safety of coenzyme Q10.
References:
Mortensen S. A., Vadhanavikit S., Muratsu K., Folkers K. 1990 Coenzyme Q10: Clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tiss Reac XII(3):155-162.
Bertelli A., Ronca G. 1990 Camitine and coenzyme Q10: Biochemical properties and functions, synergism and complementary action. Int J Tiss Reac XII(3): 183-186.
Greenberg S., Frishman W. H. 1990 Coenzyme Q10: A new drug for cardiovascular disease. J Clin Pharmacol 30:596-608.
Holford P. 1988 Co-Q: the missing energy link? Journal of Alternative and Complementary Medicine March: 21. Haas E. M. 1992 Staying healthy with nutrition, p 269-270, USA: Celestial Arts Publishing.
Suggested Dosage Coenzyme Q10 capsules:
Adults - Take one a day for the 90mg capsule, or as directed by your health professional.
Store in a cool and dry place below 30°C.
The shelf life of Coenzyme Q10 is approximately 2 years.
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